📍 Job Overview

Job Title: Senior/Principal Clinical Database Manager
Company: Precision Medicine Group
Location: Remote (UK, Spain, Hungary, Poland, Romania, Serbia, Slovakia)
Job Type: Full-Time
Category: Data Management, Clinical Research
Date Posted: August 1, 2025
Experience Level: Mid-Senior Level (5-10 years)
Remote Status: Remote (Solely)

🚀 Role Summary

Lead the design, development, and maintenance of clinical databases and applications.
Collaborate with internal teams, vendors, and clients to gather requirements and provide updates.
Provide operational and technical training to end-users and junior staff.
Play a lead role in internal software projects requiring specialized programming and/or scripting.
Demonstrate strong leadership, interpersonal, and communication skills.

📝 Enhancement Note: This role requires a balance of technical expertise in clinical database management and strong leadership skills to manage cross-functional teams and stakeholders.

💻 Primary Responsibilities

Database Development & Management: Design, develop, test, implement, and maintain clinical databases and applications using various programming languages and tools.
Stakeholder Communication: Interface with internal teams, EDC vendors, clients, and third-party vendors to gather requirements, provide status updates, and ensure project success.
Training & Mentoring: Provide operational and technical training to end-users and junior staff, fostering a culture of knowledge-sharing and continuous learning.
Project Leadership: Lead internal software projects requiring specialized programming and/or scripting, driving technical decision-making and architecture.
CDISC Standards Compliance: Ensure databases and applications adhere to CDISC standards (CDASH, SDTM, ADaM, etc.) to facilitate data exchange and interoperability.

📝 Enhancement Note: This role involves a mix of hands-on database development and management tasks, as well as strategic leadership responsibilities to drive project success and team growth.

🎓 Skills & Qualifications

Education: Bachelor's degree or a combination of related experience in a clinical, scientific, or healthcare discipline.

Experience: Minimum of 5-10 years of experience in developing and customizing clinical data management databases, with a strong background in object-oriented programming, scripting languages, SAS, R, and SQL.

Required Skills:

Rave API integration experience using external vendor modules.
Rave Advanced Custom Function programming experience.
Proficiency in Microsoft Office: Word, Excel, PowerPoint, Outlook.
Broad knowledge of drug, device, and/or biologic development and effective data management practices.
Strong leadership and interpersonal skills.
Professional use of the English language, both written and oral.

Preferred Skills:

Oncology and/or orphan drug therapeutic experience.
Base SAS®, SAS/STAT and SAS/ACCESS software.
SAS Macro programming language.
Advanced experience in database management and object-oriented programming.
Veeva set up experience.

📝 Enhancement Note: Candidates with a strong technical background in clinical database management, combined with proven leadership and communication skills, will excel in this role.

📊 Web Portfolio & Project Requirements

Portfolio Essentials:

Demonstrate a strong track record in developing and managing clinical databases, showcasing your technical expertise and problem-solving skills.
Highlight your experience with CDISC standards and data management best practices.
Include examples of successful collaborations with cross-functional teams and stakeholders.

Technical Documentation:

Provide detailed documentation of your past projects, outlining the database design, development process, testing methods, and implementation strategies.
Include any relevant code snippets, scripts, or macros that demonstrate your technical proficiency.
Showcase your ability to manage and maintain databases, highlighting any performance optimization techniques or troubleshooting experiences.

📝 Enhancement Note: A well-curated portfolio will emphasize your technical skills, leadership abilities, and proven track record in clinical database management.

💵 Compensation & Benefits

Salary Range: The salary range for this role is estimated to be €60,000 - €80,000 per year, based on regional market data and the required level of experience. This estimate takes into account the remote nature of the role and the need for candidates to have a proven track record in clinical database management.

Benefits:

Competitive benefits package, including health insurance, retirement plans, and paid time off.
Opportunities for professional development, including training and certifications.
A dynamic and collaborative work environment, with a focus on innovation and continuous learning.

Working Hours: Full-time, with a standard workweek of 40 hours. Flexible hours may be required to accommodate project deadlines and maintenance windows.

📝 Enhancement Note: The salary range provided is an estimate based on regional market data and the required level of experience. Actual compensation may vary depending on factors such as the candidate's specific skills and qualifications.

🎯 Team & Company Context

Company Culture:

Industry: Precision Medicine Group specializes in precision medicine, striking tumors on a molecular level using biomarkers to link specific mutations to specific treatments. They combine deep science with deep data from advanced technological platforms and layer on specialized expertise in the design and execution of targeted, adaptive clinical trials.
Company Size: Precision Medicine Group is a mid-sized organization with a global presence, providing ample opportunities for collaboration and career growth.
Founded: 2012 (as a subsidiary of UCB)

Team Structure:

The Clinical Database Management team is responsible for designing, developing, and maintaining clinical databases and applications that support the organization's research and development efforts.
The team works closely with internal stakeholders, including data management, project management, and clinical operations, as well as external vendors and clients.
The team is structured to support both internal and external projects, with a focus on delivering high-quality, efficient, and compliant database solutions.

Development Methodology:

Precision Medicine Group employs Agile methodologies for project management, with a focus on iterative development, continuous improvement, and collaboration.
The organization emphasizes a data-driven approach to decision-making, with a strong focus on quality, accuracy, and compliance.
The team utilizes various tools and technologies to support the development, testing, and deployment of clinical databases and applications, including Rave, SAS, and SQL Server.

Company Website: Precision Medicine Group

📝 Enhancement Note: Precision Medicine Group's focus on precision medicine and data-driven decision-making provides a unique and challenging environment for clinical database management professionals.

📈 Career & Growth Analysis

Clinical Database Management Career Level: This role is at the senior/principal level, with a focus on technical leadership, project management, and stakeholder communication. The ideal candidate will have a strong technical background in clinical database management, combined with proven leadership and communication skills.

Reporting Structure: The Senior/Principal Clinical Database Manager reports directly to the Director of Clinical Data Management. The role has both technical and managerial responsibilities, with a focus on driving project success and team growth.

Technical Impact: This role has a significant impact on the organization's research and development efforts, as it is responsible for the design, development, and maintenance of clinical databases and applications that support clinical trials and data analysis.

Growth Opportunities:

Technical Specialization: Pursue advanced certifications or specializations in clinical data management, CDISC standards, or emerging technologies to enhance your technical expertise and career prospects.
Team Leadership: Develop your leadership and management skills to take on increased responsibilities within the team or explore opportunities to lead your own team in the future.
Cross-Functional Collaboration: Expand your knowledge and skills by working with cross-functional teams, such as data management, biostatistics, and clinical operations, to drive integrated and efficient solutions.

📝 Enhancement Note: This role offers significant opportunities for career growth and development, both technically and managerially, within the organization's expanding precision medicine portfolio.

🌐 Work Environment

Office Type: Precision Medicine Group operates a hybrid work environment, with a mix of on-site and remote work options available for eligible employees. The organization has offices in several countries, including the United Kingdom, the United States, and Europe.

Office Location(s): The company has offices in the United Kingdom, the United States, Belgium, and France. Remote work is also an option for eligible employees.

Workspace Context:

Collaboration: Precision Medicine Group fosters a collaborative work environment, with a strong focus on cross-functional teamwork and knowledge-sharing.
Technology & Tools: The organization provides access to the latest tools and technologies to support the development, testing, and deployment of clinical databases and applications.
Professional Development: Precision Medicine Group offers opportunities for professional development, including training and certifications, to support the growth and advancement of its employees.

Work Schedule: Full-time, with a standard workweek of 40 hours. Flexible hours may be required to accommodate project deadlines and maintenance windows.

📝 Enhancement Note: Precision Medicine Group's hybrid work environment and focus on collaboration provide a dynamic and engaging workspace for clinical database management professionals.

📄 Application & Technical Interview Process

Interview Process:

Phone/Video Screen: A brief telephone or video call to discuss your qualifications, experience, and career goals.
Technical Assessment: A hands-on assessment of your technical skills, focusing on your ability to design, develop, and maintain clinical databases and applications.
Behavioral Interview: A structured interview to assess your leadership, communication, and problem-solving skills, as well as your cultural fit within the organization.
Final Interview: A final interview with the hiring manager and other key stakeholders to discuss your fit for the role and the organization's long-term plans.

Portfolio Review Tips:

Highlight your technical expertise and problem-solving skills through well-documented projects that demonstrate your ability to design, develop, and maintain clinical databases and applications.
Showcase your experience with CDISC standards and data management best practices, emphasizing your commitment to quality, accuracy, and compliance.
Include examples of successful collaborations with cross-functional teams and stakeholders, demonstrating your ability to drive project success and team growth.

Technical Challenge Preparation:

Brush up on your technical skills in clinical database management, with a focus on Rave, SAS, and SQL Server.
Familiarize yourself with CDISC standards and data management best practices, ensuring you can speak confidently about your approach to quality, accuracy, and compliance.
Prepare for behavioral interview questions that focus on your leadership, communication, and problem-solving skills, as well as your cultural fit within the organization.

ATS Keywords: Clinical Data Management, Database Development, Rave API Integration, Advanced Custom Function Programming, Microsoft Office, Object-Oriented Programming, Scripting Language, SAS, R, SQL, CDISC Standards, Leadership, Interpersonal Skills, Oncology Experience, SAS Macro Programming, Database Management, Precision Medicine, Clinical Research, Data Management, Clinical Trials, Clinical Databases, Clinical Applications.

📝 Enhancement Note: A well-prepared application and strong performance in the interview process will increase your chances of success in securing this competitive role.

🛠 Technology Stack & Web Infrastructure

Database Management Systems:

Rave ( preferred)
SAS ( preferred)
SQL Server ( preferred)

Programming Languages & Scripting:

Object-Oriented Programming (C#, C++, VBS, etc.)
Scripting Language (PERL, etc.)
SAS Macro Programming

Emerging Technologies & Tools:

Veeva ( preferred)
Base SAS®, SAS/STAT, and SAS/ACCESS software ( preferred)
R ( preferred)
CDISC Standards (CDASH, SDTM, ADaM, etc.)

📝 Enhancement Note: Familiarity with the preferred technologies and tools, as well as emerging trends in clinical database management, will be essential for success in this role.

👥 Team Culture & Values

Clinical Database Management Values:

Quality & Accuracy: Precision Medicine Group places a strong emphasis on quality and accuracy in clinical database management, with a focus on compliance with CDISC standards and data management best practices.
Collaboration: The organization fosters a collaborative work environment, with a strong focus on cross-functional teamwork and knowledge-sharing.
Innovation: Precision Medicine Group encourages innovation and continuous learning, with a focus on staying at the forefront of precision medicine and data management best practices.
Integrity: The organization values integrity and ethical behavior, with a commitment to maintaining the highest standards of data quality, accuracy, and compliance.

Collaboration Style:

Cross-Functional Integration: Precision Medicine Group emphasizes cross-functional integration between clinical database management, data management, project management, and other internal teams, as well as external vendors and clients.
Code Review & Quality Assurance: The organization employs code review and quality assurance practices to ensure the accuracy, efficiency, and compliance of clinical databases and applications.
Knowledge Sharing: Precision Medicine Group fosters a culture of knowledge-sharing and continuous learning, with a focus on mentoring and professional development opportunities for its employees.

📝 Enhancement Note: Precision Medicine Group's focus on quality, collaboration, innovation, and integrity provides a strong foundation for clinical database management professionals seeking to grow and develop their careers.

⚡ Challenges & Growth Opportunities

Technical Challenges:

Data Complexity: Manage complex, large-scale clinical databases and applications, requiring a strong technical background in database design, development, and maintenance.
CDISC Standards Compliance: Ensure databases and applications adhere to CDISC standards (CDASH, SDTM, ADaM, etc.), facilitating data exchange and interoperability.
Performance Optimization: Identify and implement performance optimization techniques to improve the efficiency and scalability of clinical databases and applications.
Emerging Technologies: Stay up-to-date with emerging technologies and trends in clinical database management, incorporating new tools and methodologies into your work.

Learning & Development Opportunities:

Technical Specialization: Pursue advanced certifications or specializations in clinical data management, CDISC standards, or emerging technologies to enhance your technical expertise and career prospects.
Leadership & Management: Develop your leadership and management skills through mentoring, coaching, and professional development opportunities within the organization.
Cross-Functional Collaboration: Expand your knowledge and skills by working with cross-functional teams, such as data management, biostatistics, and clinical operations, to drive integrated and efficient solutions.

📝 Enhancement Note: This role presents significant technical challenges and growth opportunities for clinical database management professionals seeking to advance their careers in precision medicine and data management.

💡 Interview Preparation

Technical Questions:

Database Design & Development: Describe your approach to designing, developing, and maintaining clinical databases and applications, with a focus on Rave, SAS, and SQL Server.
CDISC Standards Compliance: Explain your understanding of CDISC standards (CDASH, SDTM, ADaM, etc.) and their importance in clinical data management.
Performance Optimization: Discuss your experience with performance optimization techniques and strategies for clinical databases and applications.

Company & Culture Questions:

Precision Medicine Group Culture: Describe what you understand about Precision Medicine Group's culture, values, and mission, and how you would contribute to the organization's success.
Cross-Functional Collaboration: Explain your experience working with cross-functional teams, such as data management, project management, and clinical operations, and how you would drive integrated and efficient solutions.
Data Management Best Practices: Discuss your commitment to quality, accuracy, and compliance in clinical database management, with a focus on CDISC standards and data management best practices.

Portfolio Presentation Strategy:

Technical Deep Dive: Provide a detailed walkthrough of your past projects, highlighting your technical expertise and problem-solving skills in clinical database management.
Collaboration & Leadership: Showcase your experience working with cross-functional teams and stakeholders, demonstrating your ability to drive project success and team growth.
Quality & Compliance: Emphasize your commitment to quality, accuracy, and compliance in clinical database management, with a focus on CDISC standards and data management best practices.

📝 Enhancement Note: A well-prepared and tailored interview strategy will increase your chances of success in securing this competitive role.

📌 Application Steps

To apply for this Senior/Principal Clinical Database Manager position:

Customize Your Application: Tailor your resume and cover letter to highlight your technical expertise, leadership skills, and cultural fit with Precision Medicine Group.
Prepare Your Portfolio: Curate a strong portfolio that demonstrates your technical skills, problem-solving abilities, and commitment to quality, accuracy, and compliance in clinical database management.
Research the Company: Familiarize yourself with Precision Medicine Group's mission, values, and culture, ensuring you can speak confidently about your fit for the organization.
Prepare for the Interview: Brush up on your technical skills, prepare for behavioral interview questions, and practice your presentation strategy to ensure a strong performance in the interview process.

⚠️ Important Notice: This enhanced job description includes AI-generated insights and clinical database management industry-standard assumptions. All details should be verified directly with Precision Medicine Group before making application decisions.

Senior/Principal Clinical Database Manager