📍 Job Overview

Job Title: Senior/Principal Clinical Database Manager
Company: Precision Medicine Group
Location: Remote (UK, Spain, Hungary, Poland, Romania, Serbia, Slovakia)
Job Type: Full-Time
Category: Clinical Data Management
Date Posted: 2025-08-01
Experience Level: 5-10 years
Remote Status: Remote Solely

🚀 Role Summary

Lead the design, development, and maintenance of clinical databases and applications
Collaborate with internal teams, clients, and vendors to gather requirements and provide status updates
Provide operational and technical training to end users and junior staff
Play a lead role in internal software projects requiring specialized programming and/or scripting

📝 Enhancement Note: This role requires a strong technical background in clinical data management, with a focus on database development and programming. It also demands excellent communication and leadership skills to effectively collaborate with various stakeholders.

💻 Primary Responsibilities

Database Development & Management: Design, develop, test, implement, maintain, and support clinical databases and applications using various clinical database management systems
Stakeholder Communication: Interface with internal teams (Data Management, Project Management, etc.), clients, and vendors to gather requirements and provide status updates
Training & Mentoring: Provide operational and technical training to end users and junior staff, fostering a culture of knowledge sharing and continuous learning
Project Leadership: Lead internal software projects requiring specialized programming and/or scripting, driving technical decision-making and architecture
CDISC Standards Compliance: Ensure databases and applications adhere to CDISC standards (CDASH, SDTM, ADaM, etc.)
Data Management Practices: Demonstrate a broad knowledge of drug, device, and/or biologic development and effective data management practices

📝 Enhancement Note: This role requires a deep understanding of clinical data management processes, with a focus on database design, programming, and maintenance. It also necessitates strong leadership skills to drive technical projects and mentor junior staff.

🎓 Skills & Qualifications

Education: Bachelor's degree in a relevant field or a combination of related experience

Experience: Minimum of 5-10 years of experience in developing and customizing clinical data management databases in a clinical, scientific, or healthcare discipline

Required Skills:

Experience in developing and customizing clinical data management databases using various clinical database management systems
Proficiency in programming languages (C#, C++, VBS, etc.) and scripting languages (PERL, etc.)
Experience with Rave API integration using external vendor modules and Rave Advanced Custom Function programming
Understanding of CDISC standards (CDASH, SDTM, ADaM, etc.)
Strong leadership and interpersonal skills
Excellent organizational and communication skills in English (both written and oral)
Proficiency in Microsoft Office: Word, Excel, PowerPoint, Outlook

Preferred Skills:

Oncology and/or Orphan Drug therapeutic experience
Base SAS®, SAS/STAT and SAS/ACCESS software, SAS Macro programming language
Advanced experience in Database Management, object-oriented programming
Veeva set up experience

📝 Enhancement Note: This role requires a strong technical skill set, with a focus on programming, scripting, and database management. It also necessitates excellent communication and leadership skills to effectively collaborate with various stakeholders and mentor junior staff.

📊 Web Portfolio & Project Requirements

Portfolio Essentials:

Demonstrate a strong track record of developing and maintaining clinical databases and applications
Showcase projects that highlight your ability to design, develop, test, implement, and maintain clinical databases and applications
Include examples of your ability to collaborate with internal teams, clients, and vendors to gather requirements and provide status updates
Highlight your leadership skills and ability to mentor junior staff

Technical Documentation:

Provide detailed documentation of your database design, programming, and maintenance processes
Include examples of your adherence to CDISC standards and effective data management practices
Demonstrate your ability to integrate external vendor modules using Rave API and program using Rave Advanced Custom Function

📝 Enhancement Note: This role requires a strong portfolio that demonstrates your technical skills in clinical database management, with a focus on database design, programming, and maintenance. It also necessitates examples of your leadership skills and ability to collaborate with various stakeholders.

💵 Compensation & Benefits

Salary Range: £60,000 - £80,000 per annum (based on UK market rates for a Senior/Principal Clinical Database Manager with 5-10 years of experience)

Benefits:

Competitive salary and benefits package
Opportunities for professional development and growth
Flexible working arrangements, including remote work options
A dynamic and collaborative work environment focused on innovation and precision medicine

Working Hours: Full-time, with flexible hours to accommodate project deadlines and maintenance windows

📝 Enhancement Note: The salary range for this role is based on UK market rates for a Senior/Principal Clinical Database Manager with 5-10 years of experience. Benefits and working hours may vary depending on the specific location and company policies.

🎯 Team & Company Context

Company Culture:

Industry: Precision medicine, focusing on revolutionizing the attack on cancer through targeted, adaptive clinical trials
Company Size: Medium to large (global presence with multiple locations)
Founded: Not specified, but established as a leader in the precision medicine industry

Team Structure:

Collaborative, cross-functional teams consisting of data management, project management, and other specialized roles
Flat hierarchy with opportunities for growth and leadership
Strong emphasis on knowledge sharing, technical mentoring, and continuous learning

Development Methodology:

Agile/Scrum methodologies for project management and sprint planning
Code review, testing, and quality assurance practices
Deployment strategies, CI/CD pipelines, and server management for internal software projects

Company Website: Precision Medicine Group

📝 Enhancement Note: Precision Medicine Group is a leading provider of precision medicine services, with a focus on revolutionizing the attack on cancer through targeted, adaptive clinical trials. The company values collaboration, innovation, and a strong commitment to precision medicine principles.

📈 Career & Growth Analysis

Clinical Data Management Career Level: Senior/Principal Clinical Database Manager, responsible for leading the design, development, and maintenance of clinical databases and applications, with a focus on programming, scripting, and database management. This role also involves strong leadership and communication skills to effectively collaborate with various stakeholders and mentor junior staff.

Reporting Structure: This role reports directly to the Head of Data Management or a similar leadership position, with a matrix reporting structure to other internal teams as needed.

Technical Impact: The Senior/Principal Clinical Database Manager has a significant impact on the quality, accuracy, and timeliness of clinical data, ensuring that it meets CDISC standards and supports effective data management practices. This role also influences the design and implementation of internal software projects, driving technical decision-making and architecture.

Growth Opportunities:

Technical Specialization: Deepen your expertise in clinical data management, programming, and database management, with opportunities to specialize in specific therapeutic areas or technologies
Leadership Development: Develop your leadership and mentoring skills, with opportunities to lead internal software projects and mentor junior staff
Architecture & Decision-Making: Gain experience in driving technical architecture and decision-making for internal software projects, with opportunities to influence the direction of the company's technology stack

📝 Enhancement Note: This role offers significant opportunities for growth and development in the field of clinical data management, with a focus on programming, scripting, and database management. It also provides opportunities for leadership and mentoring, as well as technical specialization and architecture decision-making.

🌐 Work Environment

Office Type: Remote, with the option to work from one of the company's global offices as needed

Office Location(s): Precision Medicine Group has offices in multiple locations worldwide, including the UK, Spain, Hungary, Poland, Romania, Serbia, and Slovakia

Workspace Context:

Remote Work: Remote work options allow for flexibility and work-life balance, with the ability to work from home or a co-working space as needed
Collaboration Tools: The company provides collaboration tools and resources to support remote work and communication with internal teams, clients, and vendors
Training & Development: Precision Medicine Group offers opportunities for professional development and growth, with a focus on continuous learning and skill development

Work Schedule: Full-time, with flexible hours to accommodate project deadlines and maintenance windows. The company offers a flexible work environment that prioritizes results and productivity over strict hours.

📝 Enhancement Note: Precision Medicine Group offers a flexible and collaborative work environment, with remote work options and a strong commitment to professional development and growth. The company values a strong work-life balance and prioritizes results and productivity over strict hours.

📄 Application & Technical Interview Process

Interview Process:

Initial Screening: A brief phone or video call to assess your qualifications and fit for the role
Technical Assessment: A hands-on technical assessment or take-home project to evaluate your programming, scripting, and database management skills
Behavioral Interview: A structured interview to assess your leadership, communication, and problem-solving skills, as well as your cultural fit with the company
Final Review: A final review of your qualifications and fit for the role, with an opportunity to ask questions and discuss the company's expectations for the position

Portfolio Review Tips:

Highlight your experience in developing and maintaining clinical databases and applications, with a focus on programming, scripting, and database management
Include examples of your ability to collaborate with internal teams, clients, and vendors to gather requirements and provide status updates
Demonstrate your leadership skills and ability to mentor junior staff
Showcase your adherence to CDISC standards and effective data management practices

Technical Challenge Preparation:

Brush up on your programming, scripting, and database management skills, with a focus on clinical data management processes
Familiarize yourself with CDISC standards (CDASH, SDTM, ADaM, etc.) and effective data management practices
Prepare for questions about your leadership, communication, and problem-solving skills, as well as your cultural fit with the company

ATS Keywords: Clinical Data Management, Database Development, Programming, Scripting, CDISC Standards, Leadership, Communication, Oncology, Orphan Drug, SAS, SQL, Microsoft Office

📝 Enhancement Note: The interview process for this role is designed to assess your technical skills in clinical data management, with a focus on programming, scripting, and database management. It also evaluates your leadership, communication, and problem-solving skills, as well as your cultural fit with the company.

🛠 Technology Stack & Web Infrastructure

Database Management Systems:

Rave (EDC vendor)
Veeva Vault
Other clinical database management systems, depending on the specific project or therapeutic area

Programming & Scripting Languages:

C#, C++, VBS
PERL, other scripting languages
Base SAS®, SAS/STAT, SAS/ACCESS, SAS Macro programming language
SQL

Collaboration & Productivity Tools:

Microsoft Office: Word, Excel, PowerPoint, Outlook
Other collaboration tools, depending on the specific project or therapeutic area

📝 Enhancement Note: This role requires proficiency in various programming, scripting, and database management systems, with a focus on clinical data management processes. It also necessitates strong leadership and communication skills to effectively collaborate with internal teams, clients, and vendors.

👥 Team Culture & Values

Clinical Data Management Values:

Precision: A commitment to accurate and reliable clinical data management processes, with a focus on data quality and integrity
Collaboration: A strong emphasis on cross-functional collaboration and knowledge sharing, with a focus on driving technical projects and mentoring junior staff
Innovation: A culture of continuous learning and skill development, with a focus on emerging technologies and best practices in clinical data management
Patient Focus: A deep understanding of the patient perspective and the impact of clinical data management on patient care and outcomes

Collaboration Style:

Cross-Functional Integration: Close collaboration with internal teams, clients, and vendors to gather requirements and provide status updates
Code Review & Mentoring: A strong emphasis on code review and mentoring, with a focus on knowledge sharing and continuous learning
Knowledge Sharing: A culture of knowledge sharing, with a focus on driving technical projects and mentoring junior staff

📝 Enhancement Note: Precision Medicine Group values a strong commitment to precision, collaboration, innovation, and patient focus in clinical data management. The company fosters a culture of continuous learning and skill development, with a focus on emerging technologies and best practices.

⚡ Challenges & Growth Opportunities

Technical Challenges:

Data Quality & Integrity: Ensuring the accuracy, completeness, and consistency of clinical data, with a focus on data validation, cleaning, and transformation
Data Management Standards: Adhering to CDISC standards (CDASH, SDTM, ADaM, etc.) and effective data management practices
Data Security & Privacy: Protecting sensitive patient data and ensuring compliance with relevant regulations and guidelines
Data Analysis & Visualization: Developing and implementing data analysis and visualization tools to support effective decision-making and reporting

Learning & Development Opportunities:

Technical Specialization: Deepen your expertise in clinical data management, programming, and database management, with opportunities to specialize in specific therapeutic areas or technologies
Leadership Development: Develop your leadership and mentoring skills, with opportunities to lead internal software projects and mentor junior staff
Architecture & Decision-Making: Gain experience in driving technical architecture and decision-making for internal software projects, with opportunities to influence the direction of the company's technology stack

📝 Enhancement Note: This role offers significant opportunities for growth and development in the field of clinical data management, with a focus on programming, scripting, and database management. It also provides opportunities for leadership and mentering, as well as technical specialization and architecture decision-making.

💡 Interview Preparation

Technical Questions:

Database Management: Questions about your experience in designing, developing, testing, implementing, maintaining, and supporting clinical databases and applications
Programming & Scripting: Questions about your proficiency in programming and scripting languages, with a focus on clinical data management processes
CDISC Standards: Questions about your understanding of CDISC standards (CDASH, SDTM, ADaM, etc.) and effective data management practices
Leadership & Communication: Questions about your leadership, communication, and problem-solving skills, as well as your cultural fit with the company

Company & Culture Questions:

Precision Medicine Group: Questions about your understanding of the company's mission, values, and culture, as well as your alignment with the company's goals and objectives
Clinical Data Management: Questions about your experience in clinical data management, with a focus on programming, scripting, and database management
Patient Focus: Questions about your understanding of the patient perspective and the impact of clinical data management on patient care and outcomes

Portfolio Presentation Strategy:

Technical Demonstration: A live demonstration of your technical skills in clinical data management, with a focus on programming, scripting, and database management
Case Studies: Detailed case studies that highlight your ability to design, develop, test, implement, and maintain clinical databases and applications, as well as your leadership and mentoring skills
Problem-Solving: Examples of your problem-solving skills and ability to overcome technical challenges in clinical data management

📝 Enhancement Note: The interview process for this role is designed to assess your technical skills in clinical data management, with a focus on programming, scripting, and database management. It also evaluates your leadership, communication, and problem-solving skills, as well as your cultural fit with the company.

📌 Application Steps

To apply for this Senior/Principal Clinical Database Manager position:

Resume Optimization: Tailor your resume to highlight your experience in clinical data management, with a focus on programming, scripting, and database management. Include specific examples of your leadership, communication, and problem-solving skills.
Portfolio Preparation: Prepare a portfolio that demonstrates your technical skills in clinical data management, with a focus on programming, scripting, and database management. Include case studies that highlight your ability to design, develop, test, implement, and maintain clinical databases and applications, as well as your leadership and mentoring skills.
Interview Preparation: Familiarize yourself with the company's mission, values, and culture, as well as the specific requirements and challenges of the role. Prepare for technical questions about your programming, scripting, and database management skills, as well as leadership, communication, and problem-solving questions.
Application Submission: Submit your application through the application link provided, including your resume and portfolio. Follow the specific instructions provided by Precision Medicine Group.

⚠️ Important Notice: This enhanced job description includes AI-generated insights and clinical data management industry-standard assumptions. All details should be verified directly with Precision Medicine Group before making application decisions.

Senior/Principal Clinical Database Manager